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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX8 All Species: 11.82
Human Site: S99 Identified Species: 21.67
UniProt: Q14562 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14562 NP_004932.1 1220 139315 S99 M R P P A K P S T S K D P V V
Chimpanzee Pan troglodytes Q7YR39 1044 119631 T50 F V Q R L R D T D T L D L S G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537627 1216 138553 S99 M R P P A K P S T S K D P V V
Cat Felis silvestris
Mouse Mus musculus A2A4P0 1244 142553 S99 M R P P A K P S T S K D P V V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418105 1076 123154 P82 R L I Q T M R P P S K P S T S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002663993 1210 138002 K89 P A K A S T S K A S F P A A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610928 1242 141917 Y113 L A L P N D T Y S K K E E S D
Honey Bee Apis mellifera XP_623289 1192 136394 A94 T I K Q D E L A Q K F P V L A
Nematode Worm Caenorhab. elegans Q09530 1200 135741 K91 G D S K E D I K D S H K I T L
Sea Urchin Strong. purpuratus O17438 455 51461
Poplar Tree Populus trichocarpa XP_002318357 1207 137837 K92 K A E K E V K K D M E G D G S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38953 1168 134139 G90 S E K K K E E G D D Q K F K G
Baker's Yeast Sacchar. cerevisiae P24384 1145 129992 N90 Q V L K D D V N L D D P V V T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40 N.A. 98.5 N.A. 96.8 N.A. N.A. N.A. 84 N.A. 91.1 N.A. 69.4 71.8 61.3 21.9
Protein Similarity: 100 59 N.A. 99.1 N.A. 97.3 N.A. N.A. N.A. 86.8 N.A. 94.5 N.A. 82 83.9 75.4 28.8
P-Site Identity: 100 6.6 N.A. 100 N.A. 100 N.A. N.A. N.A. 13.3 N.A. 6.6 N.A. 13.3 0 6.6 0
P-Site Similarity: 100 26.6 N.A. 100 N.A. 100 N.A. N.A. N.A. 13.3 N.A. 13.3 N.A. 33.3 20 13.3 0
Percent
Protein Identity: 59.1 N.A. N.A. 59.3 44.2 N.A.
Protein Similarity: 75 N.A. N.A. 75.4 62.8 N.A.
P-Site Identity: 0 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 6.6 N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 24 0 8 24 0 0 8 8 0 0 0 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 16 24 8 0 31 16 8 31 8 0 8 % D
% Glu: 0 8 8 0 16 16 8 0 0 0 8 8 8 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 16 0 8 0 0 % F
% Gly: 8 0 0 0 0 0 0 8 0 0 0 8 0 8 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 8 8 0 0 0 8 0 0 0 0 0 8 0 0 % I
% Lys: 8 0 24 31 8 24 8 24 0 16 39 16 0 8 8 % K
% Leu: 8 8 16 0 8 0 8 0 8 0 8 0 8 8 8 % L
% Met: 24 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 8 0 24 31 0 0 24 8 8 0 0 31 24 0 0 % P
% Gln: 8 0 8 16 0 0 0 0 8 0 8 0 0 0 0 % Q
% Arg: 8 24 0 8 0 8 8 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 8 0 8 0 8 24 8 47 0 0 8 16 16 % S
% Thr: 8 0 0 0 8 8 8 8 24 8 0 0 0 16 8 % T
% Val: 0 16 0 0 0 8 8 0 0 0 0 0 16 31 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _